Only 18% of organizations globally have a mature practice of innovating. Building a culture of innovation is a key differentiator for successful organizations. Innovation involves challenging the status quo, improving products and processes, and positively impacting lives and the environment. To foster a culture of innovation, organizations need a framework with measurable metrics, encourage learning from failure, and provide a safe environment for experimentation. Top skills for innovation include learning agility, AI fluency, creative thinking, subject matter expertise, and critical thinking. Organizations should focus on collaborative learning, fostering experts, and providing opportunities for practice and experimentation. Fear of failure is a major obstacle to innovation, and leaders should encourage risk-taking and reward it. AI technology provides access to information, drives insights from data, and improves productivity. Startups can leverage free AI tools and collaborate with diverse talent for innovation. Ethical use of AI and critical evaluation of insights are important considerations. AI tools and data insights level the playing field for startups. Organizations should empower their people, provide time and tools for creativity, and accept failure. Innovation should be tied to a big goal and made repeatable through structure and habit. Foster a culture of innovation by valuing individuals and keeping focus on the big goal.