The Profit Cleaners podcast, hosted by Brandon Condrey and Brandon Shane, helps cleaning business owners overcome the fear of hiring employees, which can hinder growth. The hosts emphasize the importance of delegation and trusting employees, sharing strategies for effective hiring and training. They discuss financial planning to alleviate concerns and encourage a mindset shift towards embracing failure as a learning opportunity. Listeners are invited to engage and share their experiences while the hosts develop a course on cleaning processes.