Cleft palate prevalence is significantly influenced by cultural, genetic, and environmental factors. Native Americans face the highest genetic risk, followed by Asians, particularly those from China and India. Caucasians rank third, while Africans have the lowest risk. Environmental issues like poverty, poor nutrition, and pollution further elevate the risk, especially in Central and South America and Indian reservations. Additionally, historical policies, such as China's one-child policy, have led to an increase in the adoption of cleft palate children in the U.S.